Regulatory networks in colon epithelium
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The CRC-TME interaction atlas: Home
Networks
Receptor-ligand interactions in OTs
Transcriptional regulatory networks in colon/CRC epithelium
Comparison of OTs to cultured cells
Gene Expression
Differential Expression
PDOs co-cultured with TME cells
Gene Expression
Differential Expression
Enriched Pathways
TFs of interest:
AllTFs
ALX1
AR
ARID3A
ARID5B
ARNTL2
ARX
ASCL1
ATF3
ATF5
ATOH1
BACH2
BCL11A
BCL3
BHLHE40
BHLHE41
BRCA1
CDX2
CEBPA
CLOCK
CREB3L2
DBP
DDIT3
DLX2
DLX3
DLX4
DLX5
DLX6
DRGX
E2F1
E2F7
E2F8
EGR3
EHF
ELF3
ELF5
ELK3
EMX1
EN2
EPAS1
ERG
ESRRG
ETS1
ETV1
ETV4
EVX1
FEV
FLI1
FOS
FOSB
FOSL1
FOSL2
FOXA1
FOXA2
FOXA3
FOXC1
FOXC2
FOXD1
FOXD3
FOXF1
FOXF2
FOXI1
FOXK1
FOXM1
FOXO3
FOXP1
FREM1
GATA2
GATA3
GATA4
GBX2
GLI2
GRHL1
HBP1
HES1
HES2
HEY1
HHEX
HIC1
HLTF
HMGA1
HMGA2
HOXA10
HOXA13
HOXA3
HOXA5
HOXA9
HOXB13
HOXB2
HOXB4
HOXB6
HOXB8
HOXC11
HOXC8
HOXD1
HOXD10
HOXD11
HOXD13
HOXD8
HOXD9
IKZF1
IKZF2
ILF2
IRF1
IRF4
IRF7
IRF8
IRF9
IRX2
IRX3
IRX5
ISL1
ISL2
ISX
JUN
JUNB
JUND
KLF10
KLF4
KLF7
KLF8
KLF9
KMT2B
LEF1
LHX1
MAF
MAFA
MAFB
MAFF
MAFK
MAZ
MED30
MEF2C
MESP1
MITF
MSX1
MSX2
MXD1
MXD3
MXD4
MXI1
MYB
MYBL2
MYC
MYCN
NEUROD1
NEUROG3
NFAT5
NFATC1
NFE2
NFE2L3
NFIA
NFIB
NFIC
NFKB2
NKX2-1
NKX2-2
NKX2-3
NKX2-8
NR1D1
NR1H3
NR1H4
NR1I2
NR2F1
NR3C1
NR3C2
NR5A2
ONECUT2
OVOL1
PAX4
PAX7
PBX1
PITX1
PITX2
PLAG1
POU2F3
POU3F1
POU3F2
POU5F1B
PPARG
PRDM1
PRRX2
PTF1A
RARB
RFX6
RORA
RUNX1
RUNX2
RUNX3
SALL1
SATB1
SATB2
SMAD3
SMAD7
SOX1
SOX12
SOX15
SOX2
SOX30
SOX4
SOX5
SOX6
SOX7
SOX8
SOX9
SP5
SP9
SPDEF
SPI1
SPIB
SREBF1
STAT1
STAT2
TBR1
TBX10
TBX18
TBX2
TBX3
TBX4
TCF3
TCF4
TFAP2A
TFAP2C
TFDP1
TP53
TP63
TP73
TRPS1
VDR
WT1
XBP1
ZBTB20
ZBTB46
ZEB1
ZNF114
ZNF296
ZNF331
ZNF460
ZNF467
ZNF503
ZNF511
ZNF787
ZNF793
ZNF808
ZNF83
Genes of interest:
Direction of the regulation:
Upstream
Downstream
Both
Nature of the regulation:
Enhances
Inhibits
Both
Interactions to include in graph:
Positive
Negative
Both
Show only TFs (hide genes)
Yes (recommended)
No (large networks)
Hide the transcription factors with more than N targets, N=
Activate physics
Yes
No
Edge target length:
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Examples:
Regulators of CHGA expression
Regulation of enteroendocrine diff.
Overlap of enteroendocrine TFs
Overlap of secretory cell TFs
All TFs with less than 6 targets
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